Nigel Adkins makes four changes from the side that were held to a draw with Yeovil Town last weekend.
A combination of injuries and players returning from the international break has caused the changes, with Michael Hector, Danny Guthrie, Nick Blackman and Royston Drenthe all coming into the side.
Danny Williams and Pavel Pogrebnyak miss out all together through injury, whilst Kaspars Gorkss and Garath McCleary are on the bench after representing their country in midweek.
Indeed, McCleary did not return until the early hours of Friday morning after scoring for Jamaica against St. Lucia on Thursday - almost an 8,500 mile round trip! Jobi McAnuff returns on the bench after missing last week's game with the Glovers with concussion.
Hector makes his full debut for Reading.
Reading: McCarthy, Gunter, Obita, Hector, Pearce, Akpan, Guthrie (C), Blackman, Drenthe, Robson-Kanu, Le Fondre
Subs: Federici, Kelly, Gorkss, Taylor, Tshibola, McAnuff, McCleary
Brighton: Kuszczak, Saltor, Greer (C), Andrews, Ward, Forster-Caskey, Ulloa, Upson, Lopez, Lingard, Ince
Subs: Ankergren (GK), Dunk, Calderon, Obika, LukaLua, March, Buckley