Brian McDermott makes three changes from the side that lost to Southampton on Saturday.
Sean Morrison, Hal Robson-Kanu and Jason Roberts are replaced by Alex Pearce, Garath McClaery and Noel Hunt.
Sunderland make two changes to the side that lost 3-1 to Chelsea. Phil Bardsley replaced by Jack Colback, whilst top scorer Steven Fletcher is back from injury to replace Connor Wickham.
Sunderland: Mignolet, Rose, Larsson, Gardner, Colback, O'Shea (c), Johnson, McClean, Cuellar, Fletcher, Sessegnon.
Subs: Bardsley, Campbell, Wickham, Kilgallon, Vaughan, Bramble, Westwood.
Reading: Federici, Shorey, Cummings, Pearce, Mariappa, Leigertwood, Tabb, McAnuff, McCleary, Hunt, Le Fondre
Subs: Taylor, Harte, Gunter, Gorkss, Gunnarsson, Obita, Samuel