Line ups from Stamford BridgeBrian McDermott makes two changes to his starting XI from the opening day with Stoke City.
Jem Karacan makes his official return from injury after months of rehabilitation, whilst Garath McCleary makes his full debut for the Royals.
Hal Robson-Kanu and Adam Le Fondre are the men to make way.
Roberto Di Matteo makes two changes from his side's 2-0 win over Wigan - Ryan Bertrand and David Luiz are replaced by Gary Cahill and Ramires.
Reading: Federici, Gunter, Harte, Pearce, Gorkss (C), Karacan, Leigertwood, Guthrie, McCleary, McAnuff, Pogrebnyak
Subs: McCarthy, Cummings, Mariappa, Tabb, Robson-Kanu, Hunt, Le Fondre
Chelsea: Cech, Ivanovic, Cole, Cahill, Terry (C), Mikel, Ramires, Lampard, Hazard, Mata, Torres
Subs: Turnbull, Essien, Romeu, Oscar, Meireles, Sturridge, Bertrand