Karacan returns in midfieldBrian McDermott makes four changes from the side which lost 5-2 to Arsenal last weekend.
Jem Karacan makes his long awaited return from injury, whilst Chris Gunter, Ian Harte and Alex Pearce also start.
Man City: Hart, Zabaleta, K Toure, Barry, Nastasic, Rekik, Silva, Y Toure (C), Garcia, Aguero, Tevez
Subs: Wright, Lescott, Kompany, Razak, Milner, Sinclair, Dzeko
Reading: Federici, Gunter, Harte, Mariappa, Pearce, Leigertwood, Karacan, Tabb, McAnuff, Kebe, Pogrebnyak
Subs: Taylor, Shorey, Gorkss, Guthrie, Robson-Kanu, Le Fondre, Hunt