Leigertwood and Guthrie startBrian McDermott has made two changes to the side that picked up a point at Swansea prior to the international break.
Mikele Leigertwood and Danny Guthrie return to the starting line up, whilst Jay Tabb drops out - with Noel Hunt missing the trip due to injury.
Liverpool are without the services of goalkeeper Pepe Reina, and so Australian Brad Jones is handed a start.
Liverpool: Jones, Johnson, Wisdom, Skrtel, Agger, Gerrard, Allen, Suso, Sahin, Sterling, Suarez
Subs: Gulacsi, Shelvey, Henderson, Downing, Assaidi, Carragher, Enrique
Reading: McCarthy, Cummings, Shorey, Gorkss, Mariappa, Karacan, Leigertwood, Guthrie, McAnuff, Kebe, Pogrebnyak
Subs: Taylor, Gunter, Pearce, McCleary, Robson-Kanu, Le-Fondre, Roberts