Shorey, Karacan, McCleary in
Nicky Shorey, Jem Karacan and Garath McCleary all start - whilst Alex McCarthy returns to the bench after four months on the sidelines.
Adam Federici, Jimmy Kebe, Danny Guthrie and Jason Roberts miss out through injury. Pavel Pogrebnyak serves the last game of his three game suspension.
Manchester United: De Gea; Smalling, Buttner, Ferdinand, Vidic (c); Anderson, Giggs, Young; Welbeck, Rooney, van Persie #readingfc
Subs: Lindegaard, Evans, Valencia, Carrick, Kagawa, Hernandez, Powell #readingfc
Reading: Taylor, Shorey, Kelly, Pearce, Mariappa, Karacan, Leigertwood, McAnuff, McCleary, Robson-Kanu, Hunt
Subs: McCarthy, Gunter, Harte, Morrison, Akpan, Blackman, Le Fondre