Alex McCarthy, Stephen Kelly & Hal Robson-Kanu replace Adam Federici, Wayne Bridge (injured) and Adam Le Fondre. Jake Taylor and Billy Sharp have travelled but are not named on the bench; both trained at Hillsborough in the run up to kick off.
Former Reading man Michail Antonio starts for the home side, whilst new signing Connor Wickham is also named in the first XI after joining on loan from Sunderland earlier this week.
Sheff Wed: Kirkland, Buxton, Reda Johnson (C), Roger Johnson, McPhail, Olofinjana, Zayatte, Helan, Antonio, Fryatt, Wickham
Subs: Martinez, Mattock, Llera, Nuhiu, J Johnson, Coke, Palmer
Reading: McCarthy, Kelly, Gunter, Pearce, Morrison (C), Baird, Guthrie, McCleary, Obita, Robson-Kanu, Pogrebnyak