First line up for new bossSteve Clarke has made two changes to the Royals' starting XI for his first game in charge, bringing in Nick Blackman and Alex Pearce, who captains the side.
Stephen Kelly and Jake Cooper drop to the bench, whilst Hal Robson-Kanu is not involved after he and his partner celebrated the birth of a baby girl overnight. Kevin Keen has also been confirmed as Clarke's new assistant manager.
Craig Tanner also makes a welcome appearance on the substitutes bench after recovering from a knee injury.
Watford also make two changes; Daniel Pudil for coming in for Juan Carlos Paredes, and Adlene Guedioura replaceing Gianni Munari - who has a minor hamstring strain.
Reading: Federici; Gunter, Obita, Hector, Pearce (c), Norwood, Williams, McCleary, Blackman, Cox, Murray
Subs: Andersen, Cummings, Kelly, Cooper, Taylor, Stacey, Tanner
Watford: Gomes (GK); Angella, Bassong, Cathcart; Anya, Tozser, Guedioura, Abdi, Pudil; Deeney (c), Vydra. Two changes.
Subs: Bond (GK), Doyley, Paredes, Murray, Dyer, Forestieri, Ighalo.