McCleary, Blackman & Pavel startNigel Adkins makes three changes from the side that defeated Birmingham at St Andrew's on Saturday afternoon.
Danny Guthrie serves the first of a two match suspension for picking up his 10th yellow card of the season against the Blues, with Garath McCleary his replacement. Jobi McAnuff will move into central midfield to partner Hope Akpan.
Nick Blackman and Pavel Pogrebnyak are also given starts, with Hal Robson-Kanu and Adam Le Fondre dropping to the bench.
Youngster Craig Tanner will also start as substitute - the 19 year old forward rewarded after consistently impressing at U21 level this season.
Reading: McCarthy, Obita, Gunter, Gorkss, Pearce, Akpan, McAnuff (C), McCleary, Blackman, Drenthe, Pogrebnyak
Subs: Federici, Kelly, Hector, Taylor, Robson-Kanu, Tanner, Le Fondre