McCleary and Cox startRoyals boss Steve Clarke has made two changes to the line-up that started at Millwall in midweek, restoring Garath McCleary and Simon Cox to the starting line-up this afternoon.
Nick Blackman and Oliver Norwood are named on the bench, while Nathaniel Chalobah makes his Madejski Stadium debut having signed on loan from Chelsea earlier in the month.
Chris Gunter is sidelined with an ankle injury picked up at Cardiff that saw him miss out in midweek too, so Stephen Kelly continues at right-back with Jure Travner named as a substitute at Madejski Stadium for the first time.
Reading: Federici, Kelly, Obita, Hector, Pearce (c), Chalobah, Williams, Robson-Kanu, McCleary, Cox, Pogrebnyak.
Subs: Andersen, Travner, Cooper, Karacan, Norwood, Mackie, Blackman.
Sheffield Wednesday: Westwood, Mattock, Loovens, Lees, Hutchinson, Palmer, Buxton, Baker, Maguire, Maghoma, Keane.
Subs: Wildsmith, Buxton, Coke, Dielna, Helan, Nuhiu, May.