Leandro Bacuna will be making his Royals debut against Preston North End, after being put into the starting line-up on Saturday afternoon.
Bacuna comes in for Joey van den Berg, with Stephen Quinn also returning to the bench.
The attacking triumvirate of Mo Barrow, Pelle Clement and Adrian Popa will also be starting this afternoon.
Bacuna's inclusion is the only change to the Royals team that came out 2-1 victors against Aston Villa at Madejski Stadium on Tuesday night, with kick-off at Deepdale at 3pm.
Reading: Mannone, Gunter, McShane (c), Moore, Blackett, Bacuna, Swift, Kelly, Barrow, Popa, Clement.
Subs: Jaakkola, Beerens, Evans, Mendes, McCleary, Ilori, Quinn.
Preston North End: Maxwell, Fisher, Huntington (c), Davies, Earl, Maguire, Pearson, Johnson, Barkhuizen, Harrop, Hugill.
Subs: Hudson, Vermijl, Robinson, O'Connor, Spurr, Browne, Mavididi.