Dave Edwards comes straight back into the Reading starting line-up after serving a one-match suspension last time out.
That's the only change for the Royals from the weekend victory over Preston, with Tyler Blackett still missing through illness.
John Swift drops to the bench for this game, with several attacking options available for the Royals among the substitutes.
Sone Aluko starts for the first time against his former side, while Chris Martin is available from the bench against his former employers.
Reading: Mannone, Gunter (c), Moore, Ilori, Richards, Bacuna, Edwards, Kelly, Aluko, Barrow, Böðvarsson.
Subs: Jaakkola, Van den Berg, Swift, Kermorgant, Clement, Martin, Holmes.
Fulham: Bettinelli, Fredericks, Sessegnon, Odoi, McDonald, Johansen, Cairney (c), Ream, Piazon, Targett, Mitrovic.
Subs: Button, Kebano, Fonte, Norwood, Christie, Kalas, Kamara.