Paul Clement has made four changes to the starting XI which overcame Birmingham City 2-0 in midweek in the Carabao Cup.
Vito Mannone, Paul McShane, David Meyler and Liam Kelly all return to the line-up, while Marc McNulty, Liam Moore and John Swift retain their places in the line-up.
Adrian Popa also returns from injury to make the bench, with Jón Daði Böðvarsson also available as a substitute on Saturday afternoon.
Reading: Mannone, Yiadom, Blackett, McShane (c), Moore, Meyler, Swift, Kelly, Méïte, Baldock, McNulty.
Subs: Walker, O'Shea, Bacuna, Ilori, Clement, Böðvarsson, Popa.
Bolton Wanderers: Alnwick, Taylor, Lowe, Beevers, Vela, Buckley, Noone, Murphy, Olkowski, Magennis, Wheater (c).
Subs: Matthews, Oztumer, Donaldson, Wilson, O’Neil, Grounds, Wildschut.