The Royals have made three changes from the weekend draw against Derby County, with Chris Martin starting after being ineligible to face his parent club.
Garath McCleary and Joey van den Berg also start for the Royals, with Liam Kelly also continuing in midfield after his wonderstrike on Saturday.
Leandro Bacuna is likely to fill in at full-back with Omar Richards on the bench, and Sam Smith is also available from the substitutes' bench on Tuesday night.
Reading: Mannone, Gunter (c), Ilori, Moore, Bacuna, Van den Berg, Clement, Kelly, McCleary, Martin, Böðvarsson.
Subs: Jaakkola, Evans, Edwards, Barrow, Blackett, Richards, Smith.