The Royals knocked on the door but couldn't quite get the leveller against Sheffield Wednesday, who picked off Reading at the end on the counter to win 3-1.
Kadeem Harris had the visitors ahead before the break - parity was short-lived as Yakou Meite levelled and Sam Hutchinson replied instantly. The Royals poured forward but ultimatelu got caught out by Lucas Joao in added time.
Take a look at the best of the images on the opening day.