José Gomes has made four changes to the side that drew away at Bolton on Tuesday night, with Aston Villa the visitors this afternoon.
Callum Harriott, Lewis Baker, Ovie Ejaria and Tyler Blackett all come into the starting line-up at Madejski Stadium this afternoon.
Nélson Oliveira is fit to start up front after being an injury doubt in the build-up to Saturday, with Yakou Méïté available from the bench on Saturday.
For Villa, former Royals loanee Tommy Elphick lines up in central defence, with on-loan Bournemouth defender, Tyrone Mings, coming in to make his Villa debut.
Reading: Martínez, Yiadom, Moore (c), Miazga, Blackett, Rinomhota, Baker, Ejaria, Harriott, Swift, Oliveira.
Subs: Walker, Gunter, McCleary, Aluko, Barrow, Méïté, Richards.
Aston Villa: Kalinic, Taylor, Mings, Elphick, Hutton (c), Whelan, Hourihane, McGinn, El Ghazi, Adomah, Abraham.
Subs: Steer, Carroll, Jedinak, Davis, Kodjia, Elmohamady, Hause.