It'll be an all-English last eight tie in the Premier League International Cup later in February, with Reading's Under-23s set to travel up north and face Manchester United.
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The two sides have already met twice in the Premier League 2 this season, but a Semi-Final place is at stake when they face off at Leigh Sports Village on Monday 25th February, 7pm kick-off.
Scott Marshall's side are currently still competing on four fronts at the moment, with a Berks & Bucks Senior Cup tie at Flackwell Heath on Tuesday night to look forward to.
Their run in the Premier League Cup is also ongoing, making it through to the knockout stages with a game to spare, following their draw against Birmingham City on Friday afternoon.
The Premier League International Cup sees Academy sides from some of the top teams in Europe come over to England and pit their wits against their English counterparts.
The Royals have already beaten Feyenoord at Madejski Stadium this season, coupled with a dramatic draw against Sparta Prague in the group stages. Marshall's men topped their group after going unbeaten, with positive results against continental opposition preceded by a dominant victory against Leicester City in their opening group tie.
The full Quarter-Final draw is as follows:
Leicester City vs Bayern Munich
Manchester United vs Reading
Tottenham Hotspur vs Dinamo Zagreb
Southampton vs Villarreal